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Glenn N. Levine, MD

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Do you prescribe dual antiplatelet therapy to patients presenting with acute coronary syndromes on admission?


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Influence of Aspirin Resistance on Platelet Function Profiles in Patients on Long-Term Aspirin and Clopidogrel After Percutaneous Coronary Intervention

Angiolillo et al.
Am J Cardiol.  2006;97:38-43.
  KEYWORDS: Acute Coronary Syndrome , Aspirin , Cardiovascular , Percutaneous Coronary Intervention , Pharmacologic Therapy

The Incidence and Clinical Predictors of Early Stent Thrombosis in Patients with Acute Coronary Syndrome

Beinart R, Sham’a RA, Segev A, et al.
Am Heart J.  2010;159(1):118-124.
  KEYWORDS: Acute Coronary Syndrome , Stent Thrombosis

Aspirin for the Prevention of Cardiovascular Events in Patients With Peripheral Artery Disease

Berger JS, Krantz MJ, Kittelson JM, Hiatt WR.
JAMA.  2009;301(18):1909-1919.
  KEYWORDS: Aspirin , Cardiovascular , Myocardial Infarction

Incidence, Predictors, and Clinical Impact of Bleeding After Transradial Coronary Stenting and Maximal Antiplatelet Therapy

Bertrand OF, Larose E, Rodes-Cabau J, et al.
Am Heart J.   2009;157(1):164-169.
  KEYWORDS: Percutaneous Coronary Intervention , Pharmacologic Therapy

Intravenous Platelet Blockade with Cangrelor during PCI

Bhatt DL, Lincoff AM, Gibson CM, et al; for the CHAMPION PLATFORM Investigators.
N Engl J Med.  2009; Nov 15. Epub ahead of print.
  KEYWORDS: Cardiovascular
 
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Impact of Optimal Medical Therapy With or Without Percutaneous Coronary Intervention on Long-Term Cardiovascular End Points in Patients With Stable Coronary Artery Disease (from the COURAGE Trial)

Boden WE, O'Rourke RA, Teo KK, et al; for the COURAGE Trial Investigators.
Am J Cardiol.  2009;104(1):1-4.
  KEYWORDS: Percutaneous Coronary Intervention
 
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Antithrombotics in acute coronary syndromes

Bonaca MP, Steg PG, Feldman LJ, et al.
J Am Coll Cardiol.  2009;54(11):969-984.
  KEYWORDS: Acute Coronary Syndrome
 
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Body Mass Index, Periprocedural Bleeding, and Outcome Following Percutaneous Coronary Intervention (From The British Columbia Cardiac Registry)

Byrne J, Spence MS, Fretz E, et al.
Am J Cardiol.  2009;103(4):507-511.
  KEYWORDS: Percutaneous Coronary Intervention

Treatment of Clopidogrel Hypersensitivity Without Drug Interruption: Acute and Long-Term Outcomes

Campbell KL, Mallya R, Jaffrani W, et al.
Presented at: American College of Cardiology; March 29-31, Orlando, Florida.  2009
  KEYWORDS: Percutaneous Coronary Intervention , Pharmacologic Therapy

Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non–ST-segment elevation acute coronary syndrome. Primary results of the DISPERSE-2 Trial

Cannon CP et al.
J Am Coll Cardiol.  2007;50:1844-1851.
  KEYWORDS: Acute Coronary Syndrome , Cardiovascular , Hemorrhage , Myocardial Infarction , Percutaneous Coronary Intervention , Pharmacologic Therapy

Comparison of Ticagrelor With Clopidogrel in Patients With a Planned Invasive Strategy for Acute Coronary Syndromes (PLATO): A Randomized Double-Blind Study

Cannon CP, Harrington RA, James S, et al; for the PLATelet inhibition and patient Outcomes (PLATO) investigators.
Lancet.  2010. Epub ahead of print. DOI:10.1016/S0140-6736(09)62191-7.
  KEYWORDS: Acute Coronary Syndrome

Use of drug-eluting versus bare-metal stents in ST-segment elevation myocardial infarction

Chen SF, El-Bialy A, Matthews R, Clavijo L.
J Invasive Cardiol.  2009;21(11):E206-E212.
  KEYWORDS: Bare-Metal Stents , Drug-Eluting Stents
 
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Dose Effect of Clopidogrel Reloading in Patients Already on 75-mg Maintenance Dose: The Reload with Clopidogrel Before Coronary Angioplasty in Subjects Treated Long Term with Dual Antiplatelet Therapy (RELOAD) Study

Collet J-P, Silvain J, Landivier A, et al.
Circ  2008;118(12):1225-1233
  KEYWORDS: Acute Coronary Syndrome , Percutaneous Coronary Intervention , Pharmacologic Therapy

HDL-Cholesterol Level Provides Additional Prognosis in Acute Coronary Syndromes

Correia LC, Rocha MS, Esteves JP.
Int J Cardiol.  2009;136(3):307-314.
  KEYWORDS: Acute Coronary Syndrome
 
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Aspirin Noncompliance is the Major Cause of “Aspirin Resistance” in Patients Undergoing Coronary Stenting

Cuisset T, Frere C, Quilici J, et al
Am Heart J.   2009;157(5):889-893.
  KEYWORDS: Aspirin , Stent Thrombosis

Eptifibatide Provides Additional Platelet Inhibition in Non–ST-Elevation Myocardial Infarction Patients Already Treated With Aspirin and Clopidogrel: Results of the Platelet Activity Extinction in Non–Q-Wave Myocardial Infarction With Aspirin, Clopidogrel, and Eptifibatide (PEACE) Study

Dalby et al.
J Am Coll Cardiol.   2004;43:162-168.
  KEYWORDS: Acute Coronary Syndrome , Aspirin , Cardiovascular , Myocardial Infarction , Percutaneous Coronary Intervention , Pharmacologic Therapy

The reversible P2Y12 antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function.

Dovlatova NL et al.
J Thromb Haemost.  2008;6:1153-1159.
 

Predictors and impact of major hemorrhage on mortality following percutaneous coronary intervention from the REPLACE-2 trial

Feit et al.
Am J Cardiol.  2007;100:1364-1369
  KEYWORDS: Acute Coronary Syndrome , Cardiovascular , Hemorrhage , Percutaneous Coronary Intervention , Pharmacologic Therapy

Effect of Intensive Statin Therapy on Clinical Outcomes Among Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome

Gibson CM, Pride YB, Hochberg CP, et al; for the TIMI Study Group.
J Am Coll Cardiol.  2009;54(24):2290-2295.
  KEYWORDS: Percutaneous Coronary Intervention

Early Versus Delayed, Provisional Eptifibatide in Acute Coronary Syndromes

Giugliano RP, White JA, Bode C, et al for the EARLY ACS investigators
New Engl J Med.  2009;360(21):2176-2190.
  KEYWORDS: Acute Coronary Syndrome , Aspirin , Myocardial Infarction , Pharmacologic Therapy

Early Versus Delayed, Provisional Eptifibatide in Acute Coronary Syndromes

Giugliano RP, White JA, Bode C, et al, for the EARLY ACS Investigators
N Engl J Med.  2009;360(21):2176-2190
  KEYWORDS: Acute Coronary Syndrome , Percutaneous Coronary Intervention , Pharmacologic Therapy

Initial Experience With an Intravenous P2Y12 Platelet Receptor Antagonist in Patients Undergoing Percutaneous Coronary Intervention: Results From a 2-Part, Phase II, Multicenter, Randomized, Placebo- and Active-Controlled Trial

Greenbaum et al.
Am Heart J.   2006;151:689.e1-689.e10.
  KEYWORDS: Acute Coronary Syndrome , Aspirin , Cardiovascular , Percutaneous Coronary Intervention , Pharmacologic Therapy

A Review of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) and CLEAR PLATELETS 1b Studies

Gurbel et al.
Circulation.   2005;111:1153-1159.
  KEYWORDS: Aspirin , Atherothrombosis , Cardiovascular , Percutaneous Coronary Intervention , Pharmacologic Therapy

Clopidogrel Effect on Platelet Reactivity in Patients With Stent Thrombosis. Results of the CREST Study

Gurbel et al.
J Am Coll Cardiol .  2005;46:1827-1832.
  KEYWORDS: Acute Coronary Syndrome , Atherothrombosis , Bare-Metal Stents , Cardiovascular , Drug-Eluting Stents , Stent Thrombosis

Platelet Inhibition With Cangrelor in Patients Undergoing PCI

Harrington RA, Stone GW, McNulty S, et al.
N Engl J Med.  2009;361. Epub ahead of print.
  KEYWORDS: Percutaneous Coronary Intervention

Incidence of Death and Acute Myocardial Infarction Associated with Stopping Clopidogrel After Acute Coronary Syndrome

Ho PM et al.
JAMA.  2008;299:532-539.
  KEYWORDS: Acute Coronary Syndrome , Aspirin , Atherothrombosis , Cardiovascular , Myocardial Infarction , Percutaneous Coronary Intervention , Pharmacologic Therapy

Impact of the Degree of Peri-Interventional Platelet Inhibition After Loading With Clopidogrel on Early Clinical Outcome Of Elective Coronary Stent Placement

Hochholzer et al.
Am Coll Cardiol.   2006;48:1742-1750.
  KEYWORDS: Acute Coronary Syndrome , Aspirin , Atherothrombosis , Bare-Metal Stents , Cardiovascular , Drug-Eluting Stents , Percutaneous Coronary Intervention , Pharmacologic Therapy

Antiplatelet Therapy in Children

Israels et al.
Thrombosis Res.  2006;118:75-83.
  KEYWORDS: Aspirin , Atherothrombosis , Cardiovascular , Children , Pharmacologic Therapy

Long-term Safety and Efficacy of Drug-Eluting Versus Bare-Metal Stents in Sweden

James SK, Stenestrand U, Lindbäck J, et al, for the SCAAR Study Group.
N Engl J Med.  2009;360(19):1933-1945.
  KEYWORDS: Bare-Metal Stents , Cardiovascular , Drug-Eluting Stents , Myocardial Infarction , Stent Thrombosis

Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice (COMPARE): a randomised trial

Kedhi E, Joesoef KS, McFadden E, Wassing J, van Mieghem C, Goedhart D, Smits PC.
Lancet.  2010 Jan 7. [Epub ahead of print]
  KEYWORDS: Drug-Eluting Stents
  
Click for Full Abstract

2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update)

Kushner FG, Hand M, Smith SC, et al.
J Am Coll Cardiol.   2009;54(23):2205-2241.
  KEYWORDS: Acute Coronary Syndrome